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. 2015 May 18;290(33):20211–20220. doi: 10.1074/jbc.M115.638221

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Deficiency of Pim-2 activity increased Treg suppressive function. A, the Pim-2 inhibitor enhanced Treg cell suppressive function. Teff and Treg cells were cocultured in different ratios and treated with or without different concentrations of the Pim-2 inhibitor as indicated. Teff cell proliferation was analyzed by measuring the CFSE profile. B and C, Treg cell suppressive function was enhanced in Pim-2 knockout mice. Data are mean ± S.D. of three independent experiments. *, p < 0.05; **, p < 0.01 as determined by two-tailed Student's t test.