FIGURE 8.

A model demonstrating the function of Jmjd6 in regulating the activity of Tcf7l1. In the absence of Wnt activation, Tcf7l1 recruits Groucho-related proteins and functions as a transcriptional repressor to inhibit the transcription of Wnt target genes. Otherwise, Wnt activation leads to β-catenin displacement of Groucho from Tcf7l1 and turns Tcf7l1 into an activator. Jmjd6 interacts with Tcf7l1 in the Groucho-binding domain, leading to alleviation of the repression activity of Tcf7l1 even in the absence of Wnt activation. This interaction enhances the transcriptional activation that is stimulated by Wnt signaling. See text for details.