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. 2015 Jun 29;290(33):20407–20416. doi: 10.1074/jbc.M114.602276

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Biochemical pathway linking GABAT-derived glutamate to the TCA cycle is impaired in gabat^f flies. a, brain glutamate levels are reduced in gabat^f mutants. Using HPLC, we compared brain glutamate levels between gabat^f and wild-type strains after 1 day of sucrose food treatment. Independent sample t tests, *, p < 0.05. b, brain GABA levels are increased in gabat^f mutants. Using HPLC, we compared brain GABA levels between gabat^f and wild-type after 1 day of sucrose food treatment. Independent sample t tests, **, p < 0.005. c, head α-KG levels are lower in gabat^f. Using liquid chromatography-mass spectrometry, we compared head α-KG levels between wild-type and gabat^f flies after a 4-day treatment of sucrose food. Independent sample t tests, *, p < 0.05.