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Pressure inhibits heat-induced PrP oligomerization. a, oligomer molecular weight estimation (expressed as the number of equivalent monomers) by multiwavelength light scattering coupled with size exclusion chromatography. b, size exclusion chromatograms obtained after a 1-h incubation (55 °C) of PrP at atmospheric pressure (black line), 50 MPa (blue line), and 150 MPa (red line). The PrP species corresponding to each peak are indicated. a.u., arbitrary units.
