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. 2015 Jun 30;290(33):20417–20426. doi: 10.1074/jbc.M115.661710

FIGURE 4.

FIGURE 4.

Pressure alters the macrostructure of PrP oligomers. Top panels, O0; middle panels, O1; bottom panels, O3. Shown are negative stained transmission electron microscopy micrographs of untreated (1 h at 15 °C) PrP oligomers (left) and after a cycle of compression (550 MPa)/decompression at 15 °C for 1 h. Scale bars, 200 nm.