TABLE 3.
Proportion of patients with correct, insufficient, excessive dosages of rifampin in Viet Nam, 2008
| Patient characteristic | Correct (8–12 mg/kg) |
Too low (<8 mg/kg) |
Too high (>12 mg/kg) |
Total n (%) | |||
| n (row %) | 95%CI | n (row %) | 95%CI | n (row %) | 95%CI | ||
| All cases | 2806 (87.4) | 86.2–88.5 | 381 (11.9) | 10.8–13.0 | 24 (0.7) | 0.5–1.1 | 3211 (100.0) |
| Body weight group, kg | |||||||
| <25 | 4 (30.8) | 12.7–57.6 | 4 (30.8) | 12.7–57.6 | 5 (38.5) | 17.7–64.5 | 13 (0.4) |
| 25–39 | 361 (61.9) | 57.9–65.8 | 206 (35.3) | 31.6–39.3 | 16 (2.7) | 1.7–4.4 | 583 (18.2) |
| 40–55 | 2138 (94.3) | 93.2–95.2 | 127 (5.6) | 4.7–6.6 | 3 (0.1) | 0.0–0.4 | 2268 (70.6) |
| >55 | 303 (87.3) | 83.4–90.4 | 44 (12.7) | 9.6–16.6 | 0 | — | 347 (10.8) |
| Age group, years | |||||||
| 0–14 | 14 (60.9) | 40.8–77.8 | 5 (21.7) | 9.7–41.9 | 4 (17.4) | 7.0–37.1 | 23 (0.7) |
| 15–24 | 321 (92.0) | 88.6–94.4 | 28 (8.0) | 5.6–11.4 | 0 | — | 349 (10.9) |
| 25–34 | 542 (88.7) | 86.0–91.0 | 68 (11.1) | 8.9–13.9 | 1 (0.2) | 0.0–0.9 | 611 (19.0) |
| 35–44 | 494 (89.5) | 86.7–91.8 | 54 (9.8) | 7.6–12.5 | 4 (0.7) | 0.3–1.8 | 552 (17.2) |
| 45–54 | 593 (88.9) | 86.3–91.1 | 69 (10.3) | 8.3–12.9 | 5 (0.7) | 0.3–1.7 | 667 (20.8) |
| 55–64 | 308 (83.2) | 79.1–86.7 | 57 (15.4) | 12.1–19.4 | 5 (1.4) | 0.6–3.1 | 370 (11.5) |
| ≥65 | 524 (83.3) | 80.2–86.0 | 100 (15.9) | 13.2–19.0 | 5 (0.8) | 0.3–1.8 | 629 (19.6) |
| Not registered | 10 (100.0) | 72.2–100.0 | 0 | — | 0 | — | 10 (0.3) |
| Sex | |||||||
| Female | 841 (86.6) | 84.3–88.6 | 119 (12.3) | 10.3–14.5 | 11 (1.1) | 0.6–2.0 | 971 (30.2) |
| Male | 1810 (88.0) | 86.6–89.4 | 235 (11.4) | 10.1–12.9 | 11 (0.5) | 0.3–1.0 | 2056 (64.0) |
| Not registered | 155 (84.2) | 78.3–88.8 | 27 (14.7) | 10.3–20.5 | 2 (1.1) | 0.3–3.9 | 184 (5.7) |
| Disease type | |||||||
| Smear-positive pulmonary, new | 1468 (87.4) | 85.7–88.9 | 205 (12.2) | 10.7–13.9 | 7 (0.4) | 0.2–0.9 | 1680 (52.3) |
| Smear-positive, retreatment | 236 (86.4) | 81.9–90.0 | 36 (13.2) | 9.7–17.7 | 1 (0.4) | 0.1–2.0 | 273 (8.5) |
| Extra-pulmonary | 529 (86.6) | 83.6–89.1 | 74 (12.1) | 9.8–14.9 | 8 (1.3) | 0.7–2.6 | 611 (19.0) |
| Smear-negative pulmonary, new | 411 (87.6) | 84.3–90.3 | 53 (11.3) | 8.7–14.5 | 5 (1.1) | 0.5–2.5 | 469 (14.6) |
| All other | 162 (91.0) | 85.9–94.4 | 13 (7.3) | 4.3–12.1 | 3 (1.7) | 0.6–4.8 | 178 (5.5) |
| Treatment outcome | |||||||
| Cured/completed | 2516 (87.6) | 86.4–88.8 | 336 (11.7) | 10.6–12.9 | 19 (0.7) | 0.4–1.0 | 2871 (89.4) |
| Died | 95 (81.2) | 73.2–87.2 | 18 (15.4) | 10.0–23.0 | 4 (3.4) | 1.3–8.5 | 117 (3.6) |
| Failed | 37 (92.5) | 80.1–97.4 | 3 (7.5) | 2.6–19.9 | 0 | — | 40 (1.2) |
| Defaulted | 24 (85.7) | 68.5–94.3 | 4 (14.3) | 5.7–31.5 | 0 | — | 28 (0.9) |
| Transferred | 54 (96.4) | 87.9–99.0 | 2 (3.6) | 1.0–12.1 | 0 | — | 56 (1.7) |
| Not registered | 80 (80.8) | 72.0–87.4 | 18 (18.2) | 11.8–26.9 | 1 (1.0) | 0.2–5.5 | 99 (3.1) |