Table 6.
GSEA of selected MGI gene ontology categories
| Group | Geneset | Size | FDR q-val | Direction |
|---|---|---|---|---|
| Synaptic plasticity regulation | [GO:0060291] Long-term synaptic potentiation | 39 | 0.0065 | UP |
| Synaptic plasticity regulation | [GO:0048168] Regulation of neuronal synaptic plasticity | 50 | 0.0069 | UP |
| Synaptic plasticity regulation | [GO:0060292] Long term synaptic depression | 17 | 0.0070 | UP |
| Synaptic vesicle function | [GO:0016079] Synaptic vesicle exocytosis | 37 | 0.0075 | UP |
| Synaptic transmission | [GO:0050806] Positive regulation of synaptic transmission | 90 | 0.0093 | UP |
| Synaptic vesicle function | [GO:1902803] Regulation of synaptic vesicle transport | 19 | 0.0241 | UP |
| Synaptic plasticity regulation | [GO:0031914] Negative regulation of synaptic plasticity | 4 | 0.0264 | UP |
| Synaptic transmission | [GO:0001505] Regulation of neurotransmitter levels | 135 | 0.0514 | UP |
| Synaptic transmission | [GO:0050805] Negative regulation of synaptic transmission | 41 | 0.0518 | UP |
| Synaptic transmission | [GO:0035249] Synaptic transmission | 77 | 0.0800 | UP |
| Dendrite development | [GO:0097062] Dendritic spine maintenance | 9 | 0.1191 | UP |
| Synaptic transmission | [GO:0051932] Synaptic transmission | 40 | 0.1696 | UP |
| Synaptic transmission | [GO:0060075] Regulation of resting membrane potential | 4 | 0.1759 | UP |
| Synaptic transmission | [GO:0060078] Regulation of postsynaptic membrane potential [GO:0060079] Regulation of excitatory postsynaptic membrane potential | 48 | 0.1775 | UP |
| Synaptic assembly maturation | Regulation of postsynaptic membrane organization [GO:1901626] and presynaptic membrane organization [GO:1901629] | 6 | 0.2020 | UP |
| Forebrain development | [GO:0021799] cerebral cortex radially oriented cell migration | 29 | 0.1806 | DOWN |
| Forebrain development | [GO:0021794] thalamus development and [GO:0061381] cell migration in diencephalon | 11 | 0.1835 | DOWN |
| Forebrain development | [GO:0021819] layer formation in cerebral cortex | 12 | 0.2085 | DOWN |
| Axon development | [GO:0048675] axon extension | 60 | 0.2292 | DOWN |
| Forebain development | [GO:0021978] telencephalon regionalization | 13 | 0.2375 | DOWN |
Geneset enrichment analysis (GSEA) of a subset of gene ontology (GO) categories in the Mouse Genome Informatics (MGI) database. From the 51 categories listed in Additional file 9: Table S24, 20 reached the FDR q-value cutoff of 0.25. For each geneset, the number of genes in the group (size), FDR q-value, and direction is given. Categories with upward (UP) and downward (DOWN) maturational trajectories were grouped separately in the Table