Table 7.
GSEA of selected HUGO gene family categories
| Group | Gene family | Size | FDR q-val | Direction |
|---|---|---|---|---|
| Ion channels | Potassium channels (KCN) | 89 | 0.005 | UP |
| Receptors (neurotransmission) | Adrenergic Receptors (ADRA, ADRB) | 9 | 0.008 | UP |
| Structural | Lectins, sialic acid binding Ig-like (SIGLEC) | 6 | 0.091 | UP |
| Receptors (peptides) | VIP and PACAP (ADCYAP1) Receptors | 3 | 0.227 | UP |
| Ion channels | Sodium Channels (SCN) | 17 | 0.246 | UP |
| Structural | Collagens (COL) | 43 | 0.000 | DOWN |
| Structural | Kinesins (KIF) | 38 | 0.005 | DOWN |
| Structural (development) | Tubulins (TUBA) | 17 | 0.031 | DOWN |
| Structural | Extracellular matrix proteoglycans | 25 | 0.072 | DOWN |
| Structural | Major cadherins | 31 | 0.075 | DOWN |
| Structural | Protocadherins; non-clustered protocadherins | 11 | 0.090 | DOWN |
| RECEPTORS (peptides) | Vasopressin/oxytocin receptors | 4 | 0.091 | DOWN |
| Structural (development) | Caspases (CASP) | 9 | 0.091 | DOWN |
| Endogenous ligands | ADAM metallopeptidases thrombospondin type 1 (ADAMTS) | 19 | 0.091 | DOWN |
| Structural (development) | Ephrins (EFN) | 8 | 0.094 | DOWN |
| Receptors (other) | Prostanoid receptors | 8 | 0.098 | DOWN |
| Structural | Cadherin-related | 16 | 0.099 | DOWN |
| Structural (development) | EMI Domain Containing (EMID) | 7 | 0.102 | DOWN |
| Receptors (peptides) | Neuropeptide Receptors : | 9 | 0.103 | DOWN |
| Structural (development) | Mex-3 Homologs (MEX3) | 4 | 0.103 | DOWN |
| Receptors (others) | Ephrin Receptors (EPH) | 14 | 0.167 | DOWN |
| Ion channels | Acid-Sensing (Proton-Gated) Ion Channels (ASIC) | 4 | 0.169 | DOWN |
| Ion channels | Chloride Channels (Voltage Sensitive)(CLCN) | 8 | 0.173 | DOWN |
| Receptors (others) | Calcium-Sensing Receptors (CASR) | 2 | 0.186 | DOWN |
| Structural | Cell Surface Proteoglycans | 13 | 0.190 | DOWN |
| Receptors (peptides) | Hypocretin (OREXIN) Receptors (HCRTR) | 2 | 0.195 | DOWN |
| Structural | Dyneins, Axonemal (DN) | 14 | 0.205 | DOWN |
Geneset enrichment analysis (GSEA) of a subset of gene families in the HUGO database. From 111 categories listed in Additional file 9: Table S22, 27 families reached the FDR q-value cutoff of 0.25. For each gene family, the number of genes in the group (size), FDR q-value, and direction of expression (up, down) are listed. Categories with upward (UP) and downward (DOWN) maturational trajectories were grouped separately in the Table