Table 3.

Publications that reported a correlation between prognostic indicators and change in renal function or volume

Prognostic indicator	Number of publications reporting prognostic indicator	Publications reporting a significant association between prognostic indicator and rate of decrease in renal function (GFR)	Publications reporting a significant association between prognostic indicator and rate of increase in renal volume
Age e.g. age at diagnosis (years)	10	Higashihara, 2014 [101], Chen, 2014 [14], Schrier 2003 [40], Thong, 2013 [100]a, Torres, 2007 [16]a,b, Panizo, 2012 [60]a, Ozkok, 2013 [59], Marier, 2013 [49], Spithoven, 2013 [99]	Torres, 2011 [15]
			Chen, 2014 [14]
			Higashihara, 2014 [101]
Baseline TKV e.g. log10 baseline TKV (cm3)	10	Higashihara, 2014 [101], Chen, 2014 [14]d, Grantham, 2006 [46]e, Schrier, 2003 [40]f, Warner, 2012 [56], Panizo, 2012 [60]g, Lacquaniti, 2013 [98]h, Marier, 2013 [49], Torres, 2007, 2011 [15, 16]b	Chen, 2014 [14]d
			Grantham, 2006 [46]e
			Higashihara, 2014 [101]i
			Torres, 2007, 2011 [15, 16]
Baseline GFR (either estimated or measured)	6	Higashihara, 2014 [101]j, Chen, 2014 [14], Griveas, 2012 [58], Spithoven, 2013 [99]c, Torres, 2007 [16], Lacquaniti, 2013 [98]h	Chen, 2014 [14]
Proteinuria/albuminuria e.g. baseline albuminuria (mg/L)	5	Schrier, 2003 [40], Torres, 2007 [16]k, Ozkok, 2013 [59], Panizo, 2012 [60]l	Kistler, 2009 [92]
			Torres, 2007 [16]b
Blood pressure e.g. mean arterial pressure (mmHg)	4	Schrier, 2003 [40]m, Panizo, 2012 [60]n, Chen, 2014 [14]o,p, Ozkok, 2013 [59]o	Chen, 2014 [14]q
Male gender	3	None	Harris, 2006 [17]
			Kistler, 2009 [92]
			Chen, 2014 [14]
Urine sodium concentration	3	Torres, 2007 [16]	Torres, 2007, 2011 [15, 16]
			Irazabal, 2012 [48]
Protein/creatinine ratio	2	Azurmendi, 2011 [23]r	Chen, 2014 [14]
		Chen, 2014 [14]	Azurmendi, 2011 [23]s
PKD1 genotype	2	Kurashige, 2012, 2013 [95, 96]	None
Cholesterol e.g. serum HDL-c (mg/dL)	1	None	Torres, 2011 [15]s
Othert,u	14	Chen, 2014 [14], Grantham, 2006 [46], Hwang, 2013 [97], Panizo, 2012 [60], Ozkok, 2013 [59], Warner, 2012 [56], Kurashige, 2013 [96], Spithoven, 2013 [99]c, Lacquaniti, 2013 [98]h, Torres, 2007, 2010, 2011 [15, 16, 55]b, Boertien, 2010, 2012 [93, 94]	Chen, 2014 [14]

Publications of the same study have been grouped to prevent double-counting of patients

ADH antidiuretic hormone, ΔeGFR rate of decline in estimated glomerular filtration rate, eGFR estimated glomerular filtration rate, GFR glomerular filtration rate, HDL high density lipoprotein, HDL-c high density lipoprotein cholesterol, MCP1 monocyte chemoattractant protein-1, mGFR measured glomerular filtration rate, TKV total kidney volume

^aYounger age at diagnosis ^bwhen baseline GFR excluded from regression analyses ^crenal function measured by tubular secretion of creatinine ^dlog₁₀ baseline TKV correlated with annual % growth in TKV ^ebaseline TKV >1500 mL ^frenal volume; ^gkidney size; ^hrenal function assessed by combination of decrease in mGFR and increase in TKV ⁱbaseline and final TKV ^jfinal eGFR (P = 0.001) but not baseline eGFR (P = 0.401) significantly correlated with annual ΔeGFR ^kalbuminuria; ^lmicroalbuminuria; ^mmean arterial pressure ⁿdiastolic and systolic blood pressure ^ohistory of hypertension ^pintake of hypertensive drugs ^qdiastolic blood pressure and antihypertensive drug intake ^rhigh urinary albumin/creatinine ratio ^sserum HDL ^tother prognostic indicators in studies assessing disease progression by measures of renal function include: baseline creatinine, body mass index, body surface area, chronic asymptomatic pyuria, cholesterol, cyst parenchyma surface area, copeptin levels, MCP-1, plasma ADH in PKD1 patients, presence of hernia, renal blood flow, thrombocyte count, uric acid, urinary stone and urine osmolality ^uother prognostic indicators in studies assessing disease progression by measures of renal volume include: apelin levels, copeptin levels, renal blood flow, and thrombocyte count