Table 3.

Clinical, Serologic, and Histologic Features by Age at Diagnosis

	Diagnosis <40 years of age	Diagnosis >40 years of age	P-value
n	10	19
Female gender, no. (%)	9/9 (90%)	12/19 (63%)	.124
Ethnicity, no. (%)			.63
Caucasian	5/10 (50%)	1/19 (5%)
Asian	3/10 (30%)	17/19 (90%)
African American	1/10 (10%)	0/19 (0%)
Pacific Islander	1/10 (10%)	1/19 (5%)
Concomitant autoimmune disease, no. (%)	4/10 (40%)	3/19 (16%	.148
ALT, IU/L, Mean (SD)	527.4 (607.6)	527.8 (655.7)	.71
AST, IU/L, Mean (SD)	606.9 (863.5)	445.0 (545.5)	.46
Total bilirubin, mg/dL, Mean (SD)	9.4 (13.9)	7.0 (13.6)	.026
INR, Mean (SD)	1.3 (0.2)	1.1 (0.0)	>.99
Albumin, g/dL, Mean (SD)	3.9 (0.5)	4.2 (0.4)	.56
GGT, IU/L, Mean (SD)	117.4 (134.6)	95.8 (138.5)	.004
ANA positive, no. (%)	5/9 (55%)	11/12 (92%)	.019
SMA positive, no. (%)	2/7 (29%)	5/9 (56%)	.28
Histology consistent with AIH, no. (%)	5/7 (71%)	13/14 (93%)	.186
Cirrhosis present on biopsy, no. (%)	4/7 (57%)	5/12 (42%)	.52
Presentation, no. (%)			.60
Acute	1/8 (13%)	5/16 (31%)
Insidious	5/8 (63%)	7/16 (44%)
Asymptomatic	2/8 (25%)	4/16 (25%)
Treatment response, no. (%)			.093
Complete remission	5/8 (63%)	13/18 (72%)
Partial remission	2/8 (25%)	3/18 (17%)
No remission	1/8 (13%)	2/18 (11%)

Abbreviations: standard deviation (SD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), International normalized ratio (INR), gamma-glutamyl transferase (GGT), anti-nuclear antibody (ANA), smooth muscle antibody (SMA), autoimmune hepatitis (AIH). Three patients had an unknown age of diagnosis and were excluded from this analysis.

One-way analysis of variance was used to test the differences in the means of continuous variables, and chi-squared tests were used to test differences between categorical variables.