Figure 4.

Amyloid plaques detected with in vivo mMRI after intravenous femoral injection of USPIO-PEG-Aβ1-42.

Notes: (A) In vivo T2*-weighted mMRI images of a 14-month-old APP/PS1 transgenic mouse. (B) A higher magnification of the area in the red box shown in (A). Arrowheads highlight some amyloid plaques detected by mMRI. (C) In vivo mMRI of a 16-month-old wild-type mouse after intravenous femoral injection of USPIO-PEG-Aβ1-42. (D) A higher magnification of the area in the red box shown in (C). Adapted with permission from Wadghiri YZ, Li J, Wang J, et al. Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer’s disease transgenic mice using magnetic resonance microimaging. PLoS One. 2013;8(2):e57097.¹²⁰

Abbreviations: mMRI, magnetic resonance microimaging; USPIO, ultrasmall superparamagnetic iron oxide; PEG, polyethylene glycol.