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. 2015 Aug 10;10:4919–4936. doi: 10.2147/IJN.S82310

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© 2015 Velasco-Aguirre et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Strategies to enhance the delivery of AuNPs to the CNS.

Notes: Left: Intranasal administration of functionalized AuNPs that recognize the target in the brain. For the mucoadhesion of the nanoparticles to the mucosa, the nanoparticles could be capped with a polymer. Right: AuNPs capped with PEG diminish the interaction with plasma proteins, a peptide that recognizes the receptor (represented in yellow as a semicircle) for RMT and a peptide that recognizes the therapeutic target (green triangles). Note that AuNPs are not scaled with respect to the cells, brain, and organism.

Abbreviations: AuNPs, gold nanoparticles; CNS, central nervous system; PEG, polyethylene glycol; RMT, receptor-mediated transcytosis; BBB, blood–brain barrier.