Table 1.
Preclinical uses of peptides and proteins in the delivery of metal nanoparticles and their potential applications
| Metal nanoparticles | Peptide used | Therapeutic target | Year | Authors |
|---|---|---|---|---|
| GNS | CLPFFD | Overcome the BBB, in vivo | 2010 | Guerrero et al110 |
| GNS | CLPFFD-THR | Overcome the BBB for neurodegenerative disorders | 2012 | Prades et al115 |
| GNS | CLPFFD | Overcome the BBB, in vivo | 2012 | Guerrero et al111 |
| Spherical silica cores and thin gold shells | VEGF | Glioma potential treatment | 2012 | Day et al116 |
| CdSe/ZnS core–shell quantum dots | Palm1 | Delivery of neurotherapeutics to neurons | 2012 | Walters et al117 |
| Iron oxide | Fibrin γ377–395 peptide | Inhibition of microglial cells | 2013 | Glat et al118 |
| PEG-superparamagnetic iron oxide | Aβ1-42 | Detection of amyloid plaques in vivo | 2013 | Wadghiri et al120 |
| PEG-GNS | Fragment of the neural cell adhesion molecule L1 | Drug delivery platform for neurons | 2013 | Schulz et al119 |
| GNSs | KRGD-PEGSH | Photoacoustic detection of glioma | 2011 | Lu et al121 |
| Gold glyconanoparticles | C11-Glycopep, C11-Enk peptide | Overcome the BBB, in vivo distribution, PET reporter | 2014 | Frigell et al122 |
| GNS | Insulin | Improve brain delivery of AuNPs | 2014 | Shilo et al125 |
| GNS | Albumin or ApoE | Biodistribution studies | 2014 | Schäffler et al124 |
Abbreviations: GNS, gold nanosphere; BBB, blood–brain barrier; VEGF, vascular endothelial growth factor; PEG, polyethylene glycol; PET, positron emission tomography; AuNPs, gold nanoparticles; ApoE, apolipoprotein-E.