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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Nat Chem Biol. 2015 Apr 20;11(6):416–423. doi: 10.1038/nchembio.1796

Figure 2. Rapid-dilution progress curves for P. aeruginosa LpxC inhibitors establish residence time.

Figure 2

Progress curve data for P. aeruginosa LpxC inhibitors at 37 °C. Legend indicates compound 1–6. Reactions were conducted under conditions where compound rebinding after disassociation is minimized and the observed time constant for reactivation is indicative of the residence time.