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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: Angew Chem Int Ed Engl. 2014 Jul 2;53(34):8840–8869. doi: 10.1002/anie.201310843

Figure 4.

Figure 4

Human chemical evolution of tetracycline and macrolide antibiotics by semisynthesis (important new structural features of each generation are highlighted in blue).