Table 1. The most representative cancer-related epi-miRNAs and their targets.
| epi-miRNA | Epigenetic target(s) | Cancer | Reference |
|---|---|---|---|
| miR-29a/b/c | DNMT3A, DNMT3B | AML, MM, NSCLC | [28, 42, 81] |
| miR-148a/b | DNMT1 | GC, HC | [46, 184, 185] |
| miR-152 | DNMT1 | GC, BC, OC, NB | [46, 186, 187] |
| miR-217 | DNMT3A | CML | [188] |
| miR-1741 miR-16c miR-222 miR-1632 |
DNMT3A DNMT3B |
OC | [47] |
| miR-185 | DNMT1 | TN-BC, OC | [186, 189] |
| miR-140 | DNMT1 | HC | [190] |
| miR-342 | DNMT1 | CC | [191] |
| miR-143 | DNMT3A | CML | [192] |
| miR-199a-3p | DNMT3A | TC | [193] |
| miR-9* | HDAC4 HDAC5 |
WM | [74] |
| miR-34a | HDAC1 HDAC7 |
BC | [79] |
| miR-874 | HDAC1 | HN | [194] |
| miR-520h | HDAC1 | GC | [195] |
| miR-449a | HDAC1 | PC | [196] |
| miR-145 | HDAC2 | HC | [197] |
| miR-206 | HDAC4 | GC | [198] |
| miR-200a | HDAC4 | HC | [199] |
| miR-200b | SUZ12 | BC | [200] |
| miR-101 | EZH2 | Endometrial cancer | [52] |
| miR-101 | EZH2 | GC | [201] |
| miR-26a, miR-214, miR-32 | EZH2 | Oral cancer GC |
[55] [202] [203] |
| miR-15a/miR-16 | Bmi-1 | OC | [58] |
| miR-203 | Bmi-1 | EC | [59] |
| miR-200c | Bmi-1 | Melanoma | [63] |
| miR-128 | Bmi-1 | BC | [61] |
| miR-26a, miR-31, miR-203 | MMSET | PC | [68] |
Abbreviations: AML, Acute Myeloid Leukemia; BC, Breast Cancer; CML, Chronic Myeloid Leukemia; EC, Esophageal Cancer; GC, Gastric Cancer; HC, Hepatocellular Carcinoma; HN, Head and Neck Cancer; MM, Multiple Myeloma; NB, Neuroblastoma; NSCLC, Non Small Cell Lung Cancer; OC, Ovarian Cancer; PC, Prostate Cancer; TN-BC, Triple Negative Breast Cancer.