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. 2015 May 7;6(15):12890–12908. doi: 10.18632/oncotarget.3849

Figure 2. Basal-like TNBC.

Figure 2

Drug classes previously evaluated or currently being investigated in breast cancer clinical trials are shown. *More than 100 studies of anti-IGFR1 therapy (anti-receptor Abs, anti-ligand Abs, receptor-TKIs, and metformin) have been conducted. **Many combination drugs are currently being investigated: EGFR and HER2-TKIs (e.g., lapatinib and BIBW2992), c-MET and VEGFR-TKIs (e.g., cabozantinib) or FGFR and VEGFR-TKIs (e.g., lucitanib, dovitinib, BIBF1120).

Abbreviations: BER, base-excision repair; CDK, cyclin-dependent kinase; EGFR, epidermal growth factor receptor; FGFR, fibroblast growth factor receptor; IGFR, insulin growth factor receptor; HR, homologous recombination; mAb, monoclonal antibody; TKI, tyrosine-kinase inhibitor; VEGFR, vascular endothelial growth factor receptor.