Table 2. Effect of TP3, methicillin and vancomycin on mice survival following intraperitoneal injection of 1×106 CFU of MRSA each mouse.
Strain and %Treatment | % lethality | Mean ± SD count (CFU/ml) | ||||
---|---|---|---|---|---|---|
Blood | Peritoneum | Spleen | Liver | Mesenteric lymph nodes | ||
MRSA | ||||||
MRSA+PBS | 20B | 5.8×107±1.4×107B | 1.x1010±3.6×109B | 6.8×108±3.x108B | 2.1×108±9.2×107B | 5.4×107±2.6×107B |
MRSA+Methcillin(0.01 mg/g) | 20B | 5.8×107±1.7×107B | 4.9×109±2.2×109B | 9.5×108±1.9×108B | 3.7×108±8.1×107B | 6.4×107±5.3×107B |
MRSA+Vancomycin(0.01 mg/g) | 0A | 8×105±1.3×106B | 2.7×109±1.5×109A | 1.8×108±8.4×107B | 1.7×108±3.8×107B | 2×106±4.4×106A |
MRSA+TP3(0.005 mg/g) | 0A | 0A | 1.4×109±1×109A | 9×107±8.2×107A | 4.4×107±1×107A | 1.6×106±1×106A |
Lethality was monitored for 2 day following the injection of TP3 or antibiotic.