Table 2. Top 10 KEGG pathways enriched in small and large abdominal aortic aneurysm.

Category	Pathway	KEGG	N	n	P value
Small AAA-upregulated genes	Cytokine-cytokine receptor interaction	hsa04060	267	15	1.15*10−14
	Chemokine signaling pathway	hsa04062	190	11	4.50*10−11
	Hematopoietic cell lineage	hsa04640	88	7	3.68*10−08
	NOD-like receptor signaling pathway	hsa04621	62	6	1.18*10−07
	Cell adhesion molecules (CAMs)	hsa04514	134	7	4.15*10−07
	Jak-STAT signaling pathway	hsa04630	155	7	9.36*10−07
	Intestinal immune network for IgA production	hsa04672	50	4	4.07*10−05
	T cell receptor signaling pathway	hsa04660	108	5	4.07*10−05
	Cytosolic DNA-sensing pathway	hsa04623	56	4	5.46*10−05
	Pathways in cancer	hsa05200	330	7	8.39*10−05
Small AAA-downregulated genes	Ribosome	hsa03010	88	27	2.50*10−26
	Metabolic pathways	hsa01100	1104	69	2.30*10−22
	Oxidative phosphorylation	hsa00190	135	26	4.25*10−20
	Parkinson's disease	hsa05012	133	25	3.60*10−19
	Alzheimer's disease	hsa05010	169	27	6.00*10−19
	Huntington's disease	hsa05016	185	28	6.00*10−19
	Focal adhesion	hsa04510	201	23	5.48*10−13
	Cardiac muscle contraction	hsa04260	79	15	7.66*10−12
	Arrhythmogenic right ventricular cardiomyopathy	hsa05412	76	11	1.65*10−07
	Vascular smooth muscle contraction	hsa04270	115	13	1.65*10−07
Large AAA-upregulated genes	Cytokine-cytokine receptor interaction	hsa04060	267	20	2.52*10−17
	Chemokine signaling pathway	hsa04062	190	14	3.53*10−12
	Hematopoietic cell lineage	hsa04640	88	10	9.95*10−11
	Primary immunodeficiency	hsa05340	35	7	1.89*10−09
	Cell adhesion molecules (CAMs)	hsa04514	134	9	7.87*10−08
	Intestinal immune network for IgA production	hsa04672	50	6	6.70*10−07
	Cytosolic DNA-sensing pathway	hsa04623	56	6	1.15*10−06
	NOD-like receptor signaling pathway	hsa04621	62	6	1.86*10−06
	Jak-STAT signaling pathway	hsa04630	155	8	2.30*10−06
	T cell receptor signaling pathway	hsa04660	108	7	2.40*10−06
Large AAA-downregulated genes	Metabolic pathways	hsa01100	1104	78	1.05*10−24
	Huntington's disease	hsa05016	185	31	3.64*10−20
	Oxidative phosphorylation	hsa00190	135	27	8.60*10−20
	Alzheimer's disease	hsa05010	169	28	2.45*10−18
	Parkinson's disease	hsa05012	133	25	7.70*10−18
	Ribosome	hsa03010	88	18	1.32*10−13
	Cardiac muscle contraction	hsa04260	79	16	4.25*10−12
	Focal adhesion	hsa04510	201	23	8.41*10−12
	Vascular smooth muscle contraction	hsa04270	115	17	1.27*10−10
	Fatty acid metabolism	hsa00071	42	10	1.70*10−08

AAA, abdominal aortic aneurysm; N, number of reference genes in the pathway; n, number of genes differentially expressed in pathway in small or large AAA compared to patients without AAA (Controls); > 2-fold difference, P value < 0.05 calculated with non-parametric Mann-Whitney test and corrected by Benjamini and Hochberg method. P value indicates the corrected significance of enrichment calculated from the hypergeometric test by Benjamini and Hochberg method. Pathways were identified using WebGestalt and were linked to the KEGG (Kyoto Encyclopedia of Genes and Genomes) website http://www.genome.jp/kegg/.