Figure 6. ARHGAP5 expression is upregulated in NPC cell lines and associated with tumor progression as well as miR-744 expression in NPC clinical specimens.

a. The expression of ARHGAP5 mRNA and protein in NPC cell lines were analyzed by qRT-PCR and western blot. b. ARHGAP5 expression in different clinical stages of NPC. c. Upregulation of ARHGAP5 in NPC was associated with more serious lymph node metastasis. d. ARHGAP5 up-regulation was significantly correlated with miR-744 up-regulation in clinical human NPC tissues. e. Correlation of miR-744 and ARHGAP5 mRNA expression in NPC cell lines. f. Schematic model of the potential signaling mechanism between miR-744 and ARHGAP5 in the regulation of NPC cell motility.