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. 2015 Apr 23;6(15):13201–13215. doi: 10.18632/oncotarget.3915

Figure 6. miR-1 inhibited ccRCC tumor growth in subcutaneously and orthotopic.

Figure 6

A. a. Photographs of tumors excised 51 days after inoculation of stably transfected cells into nude mice; b. mean tumor volume measured by caliper on the indicated days; c. IHC staining for PCNA, Caprin1, CDK4, CDK6 and Slug in slices of sectioned implanted tumors formed by indicated cells. Original magnification was ×200; d. Correlation of miR-1 with Caprin1, CDK4, CDK6 and Slug in subcutaneous transplantation tumor. B. a. Macroscopic appearance of the tumor xenograft (arrows) in nude mice from the 7th-week. L, left kidney; R, right kidney. b. Representative fluorescence images with primary tumors in the left kidney of nude mice after orthotopic injections of Lenti-miR-1 or Lenti-miR-NC for 7 weeks (arrows). c. H&E staining of the tumor xenograft. N, normal renal tissues; T, primary renal tumors. Original magnification was ×200. C. MiR-1 family modulates G1/S transition by regulating Cdk4/6-cyclin D complexes and Caprin1. Moreover, miR-1 can inhibit metastasis by downregulation of Slug.