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. 2015 Apr 19;6(15):13462–13475. doi: 10.18632/oncotarget.3880

Figure 7. ADCC-induced cytotoxicity of ARGX-110.

Figure 7

A. Percentage of cell survival 24h after treatment compared to the isotype control (set at 100%). Bars represent the mean±SD (n = 3). *p < 0.05: significant decrease in cell survival by ARGX-110 in comparison to isotype control with identical E/T ratio. B. CRL-5908 cells were incubated with ARGX-110 (red), NK cells (5/1) in combination with ARGX-110 (Green) or with isotype control (blue). The well impedance, expressed by the cell index as a measure of viability, was analysed using the xCELLigence system as described in the material and methods section. Cell indexes were normalized with the last point before compound addition, as indicated by the arrow. Graph represents mean±SD. C. Percentage of cell survival of a CD70+ (CRL-5908) and a CD70- (CRL-5883) cell line 24h after treatment with ARGX-110 with different ratios of NK cells (1/1 – 5/1 – 10/1). *P < 0.05: significant decrease in cell survival in comparison to E/T ratio of 1/1. For all experiments, two replicates of the same condition were measured and run in parallel with NK cells from three different donors.