Table 4. Univariate and multivariate analysis for pathological response to neo-adjuvant chemotherapy in IBC.
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| N | OR [CI95] | p-value | N | OR [CI95] | p-value | |
| Age, years > 50 vs. <=50 | 64 | 0.72 [0.29–1.72] | 0.533 | |||
| Histological type, other vs. ductal | 64 | 0.38 [0.04–1.94] | 0.392 | |||
| Histological grade, 3 vs. 2 | 60 | 1.11 [0.42–3.05] | 0.859 | |||
| ER status, positive vs. negative | 66 | 0.58 [0.24–1.37] | 0.296 | |||
| PR status, positive vs. negative | 66 | 0.36 [0.14–0.86] | 0.059 | 66 | 0.49 [0.17–1.38] | 0.258 |
| ERBB2 status, positive vs. negative | 66 | 0.48 [0.15–1.3] | 0.247 | |||
| Molecular subtypes, ERBB2-enriched vs. basal | 66 | 0.95 [0.28–3.18] | 0.947 | |||
| Luminal A vs. basal | 66 | 0.24 [0.05–0.94] | 0.110 | |||
| Luminal B vs. basal | 66 | 0.67 [0.16–2.55] | 0.627 | |||
| Normal-like vs. basal | 66 | 0.5 [0.12–1.81] | 0.391 | |||
| PDL1 group, high vs. Low | 66 | 3.44 [1.42–8.63] | 2.33E–02 | 66 | 3.49 [1.28–10.1] | 4.46E–02 |
| FAC/T response signature, “pCR-predicted” vs. “no pCR-predicted” | 66 | 3 [1.22–7.54] | 4.60E-02 | 66 | 1.58 [0.53–4.7] | 0.487 |
| Stromal signature, “pCR-predicted” vs. “no pCR-predicted” | 66 | 2.86 [1.18–7.08] | 0.052 | 66 | 3.28 [1.25–9.17] | 0.047 |