Figure 2. SYK023 activates caspase cascade and induces ER stress in vivo.

A. Effects of BA and SYK023 on lung tumor progression in Kras^G12D and EGFR^L858R transgenic mice. After treatment with BA or SYK023 (10 mg/kg), lungs were excised for histological staining. Scale bar means 1 cm. B. The number of tumor nodules on lung surface of Kras^G12D mice. The serum was collected for evaluating liver and kidney functions. Data are expressed as mean±s.e.m. *P < 0.05, **P < 0.01 and ***P < 0.001. C. The whole tissue extracts of lungs were prepared for Western blotting. The mRNA was subjected to reverse transcription and Q-PCR. Data are expressed as mean±s.e.m, P-value is indicated.