Table 1. The physiological parameters of mice receiving DMSO, BA or SYK023.
| Mice | Parameters | DMSO (D) | BA | SYK023 | D vs BA | D vs SYK |
|---|---|---|---|---|---|---|
| Kras4bG12D (n=8) | ALP (U/L) | 233±15.2 | 197±14.8 | 182±16.1 | P=0.1118 | P=0.0375* |
| GOT (U/L) | 51.9±7.9 | 48±2.9 | 50.9±6.2 | P=0.6509 | P=0.9217 | |
| GPT (U/L) | 38.4±6.2 | 30.6±3.2 | 38.1±2.8 | P=0.2843 | P=0.9711 | |
| BUN (mg/dl) | 25.5±2 | 29.6±1.6 | 26.1±1.7 | P=0.1279 | P=0.8141 | |
| CRE (mg/dl) | 0.6±0.08 | 0.5±0.08 | 0.4±0.09 | P=0.6160 | P=0.2158 | |
| SCID (n=6) | ALP (U/L) | 153.5±24.6 | 100.3±3.6 | 116.2±8 | P=0.0586 | P=0.1803 |
| GOT (U/L) | 93.8±18.8 | 121±16.1 | 104.8±5 | P=0.2977 | P=0.5838 | |
| GPT (U/L) | 28.8±3.7 | 26.3±4.2 | 17.7±2.4 | P=0.6660 | P=0.0303* | |
| BUN (mg/dl) | 29.7±1.4 | 33.7±3.1 | 36.9±6.2 | P=0.2703 | P=0.2774 | |
| CRE (mg/dl) | 0.4±0.04 | 0.5±0.1 | 0.6±0.1 | P=0.3293 | P=0.1284 |
Data were expressed as mean±s.e.m.
*
P<0.05