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Schematic representation of the molecular machinery involved in A. mother fed group (MF) where TR binds the TRE element of the glut4 gene transcription to result in Glut4 mRNA, and B. early postnatal high carbohydrate diet (HC) induced recruitment of nuclear proteins responsible for epigenetic control of the glut4 gene in rat skeletal muscle to interact with the TR-TRE complex, which results in reduced Glut4 mRNA that translates into decreased Glut4 protein.
