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. 2015 Aug 14;10(8):e0135805. doi: 10.1371/journal.pone.0135805

Table 3. Management of urate-lowering therapy (ULT) during an acute gouty attack and anti-inflammatory prophylaxis of gout attacks.

Questions and respective options Proportion (95% CI)
During an acute gouty attack in a patient using ULT, you: [N = 309]
Increase the ULT dose 0.3 (0.0–1.0)
Keep the ULT dose 1 67.0 (61.7–72.3)
Reduce the ULT dose 1.3 (0.0–2.6)
Withdraw the ULT 31.4 (26.2–36.6)
How often do you give prophylactic treatment to prevent acute gouty attacks when initiating ULT? [N = 302]
Always 1 64.9 (59.5–70.3)
Almost always 1 27.5 (22.4–32.5)
Sometimes 3.6 (1.5–5.8)
Almost never 1.7 (0.2–3.1)
Never 2 2.3 (0.6–4.0)
How long do you keep prophylaxis for patients WITHOUT tophi? [N = 295]
<1 month 16.9 (12.6–21.3)
1–6 months 42.4 (36.7–48.0)
7–12 months 10.8 (7.3–14.4)
Until they reach the target serum uric acid level 20.0 (15.4–24.6)
Indefinitely 9.8 (6.4–13.2)
How long do you keep prophylaxis for patients WITH tophi? [N = 295]
<1 month 5.1 (2.6–7.6)
1–6 months 23.4 (18.5–28.2)
7–12 months 15.6 (11.4–19.8)
Until they reach the target serum uric acid level 13.9 (9.9–17.9)
Until resolution of tophi 7.5 (4.4–10.5)
Indefinitely 34.6 (29.1–40.0)
Do you prefer colchicine or NSAID for chronic prophylaxis of acute gouty attacks? [N = 295]
Colchicine 97.6 (95.9–99.4)
NSAID 2.4 (0.6–4.1)

1Answers in agreement with the 2012 ACR gout guidelines

2participants who answered not to prescribe anti-inflammatory prophylaxis when initiating ULT were excluded from the other questions concerning this topic.

CI: confidence interval; NSAID: nonsteroidal anti-inflammatory drug.