Table 1. Inhibition of nicotinic responses in CN21 and SH-SY5Y cells.
| CN21 | SH-SY5Y | ||||
|---|---|---|---|---|---|
| Test compound | n | Log IC50 (M) | Hill slope | Log IC50 (M) | Hill slope |
| MB775 | 1 | DNC | DNC | - | - |
| MB520 | 2 | -2.06 ± 0.04 | -0.75 ± 0.06 | - | - |
| MB408 | 3 | -2.37 ± 0 26 | -0.73 ± 0.06 | - | - |
| MB444 | 4 | -2.51 ± 0.15 | -0.72 ± 0.05 | -3.27 ± 0.04 | -1.81 ± 0.26 |
| MB442 | 5 | -2.56 ± 0.16 | -0.60 ± 0.13 | -4.01 ± 0.04 | -2.10 ± 0.40 |
| MB776 | 6 | -3.50 ± 0.32 | -0.50 ± 0.02 | -4.54 ± 0.04 | -1.88 ± 0.24 |
| MB777 | 7 | -4.81 ± 0.23 | -0.72 ± 0.01 | -4.43 ± 0.05 | -1.80 ± 0.30 |
| MB505 | 8 | -5.30 ± 0.20 | -0.99 ± 0.07 | -4.76 ± 0.03 | -1.74 ± 0.22 |
| MB778 | 9 | -5.94 ± 0.11 | -1.56 ± 0.11 | -5.38 ± 0.04 | -1.66 ± 0.20 |
| MB779 | 10 | -6.05 ± 0.17 | -1.34 ± 0.14 | -5.78 ± 0.03 | -1.28 ± 0.09 |
Log IC50 values for inhibition of nicotinic responses in CN21 and SH-SY5Y cells by the test compounds. Data show mean ± SEM. All values were obtained by best-fit of the Hill-equation as described in the methods section. DNC = fit did not converge.