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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: BJU Int. 2012 Apr 30;110(8 0 0):E409–E414. doi: 10.1111/j.1464-410X.2012.11189.x

FIG. 3.

FIG. 3

Inhibition of P2X3/P2X2/3 receptors attenuates the pressure- and ATP-induced increase in afferent neural activity. Representative neuronal activity traces in normal control (NL; A, B) and SCI (D, E) rats before and after i.v. AF-353 (10 mg/kg). Systemic application of AF-353 significantly decreased the generation of field potentials in NL (**P < 0.01; C) and SCI (**P < 0.01; F) rats. Traces represent 5 s of afferent activity. Data from the 60 cmH2O with intravesical ATP from Fig. 2 were merged for comparison. Bars represent the mean ± sem for six NL and five SCI rats.