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. Author manuscript; available in PMC: 2015 Aug 14.
Published in final edited form as: Biomed Environ Sci. 2014 May;27(5):360–370. doi: 10.3967/bes2014.061

Table 2.

Top Eight SNPs Showing Significant Evidence for Associations with BMI (FDR q values≤0.05) in GWA Analyses

dbSNP ID Chromosome
Position
Physical
Position
Associated
GeneA
Role Allele MAFB MAFC P Value q
Value
rs4633 22q11.21 18330235 COMT Exon3 T/C 0.254 0.233 5.45×10−7 0.033
rs3213523 22q13.32 48131411 FU44385 Upstream C/T 0.352 0.422 2.75×10−6 0.048
rs1438168 3p25.3 10412280 ATP2B2 Intron4 G/A 0.409 0.389 2.82×10−6 0.048
rs10904363 10p15.1 4910413 AKR1CL2 Intron5 C/G 0.417 0.356 3.24×10−6 0.048
rs711906 15q15.1 38112983 EIF2AK4 Intron37 A/G 0.470 0.489 4.38×10−6 0.048
rs4432245 15q15.1 38111773 EIF2AK4 Intron36 C/T 0.481 0.489 6.39×10−6 0.048
rs7623901 3q13.33 123011701 IQCB1 Intron5 T/C 0.053 0.056 6.41×10−6 0.048
rs12496318 3q13.33 123044190 EAF2 Intron1 T/G 0.054 0.056 7.26×10−6 0.048

Note.

A

Abbreviations: COMT (catechol-O-methyltransferase), EIF2AK4 (eukaryotic translation initiation factor 2 alpha ki nase 4), FU44385 (uncharacterized), ATP2B2 (plasma membrane Ca(2+)-ATPase), AKR1CL2 (aldo-keto reductase family 1, member C-like 2), IQCB1 (IQ motif containing B1), EAF2 (ELL associated factor 2);

B

Minor allele frequency calculated in initial GWA sample;

C

Minor allele frequency reported for the Chinese or Asians in the public database such as HapMap or dbSNP.