Table 3.

Analyzed SNPs in EIF2AK4 Gene for the GWA Sample

Associated Gene	dbSNP	Physical Position	Role	AlleleA	MAFB	MAFC	P ValueD	FDR q ValueE
EIF2AK4 (15q15.1)	rs534757	38014169	Intron 1	T/C	0.167	0.144	0.624 814	NS
	rs518770	38017564	Intron 1	T/C	0.166	0.144	0.677 616	NS
	rs489508	38033071	Intron 4	T/C	0.016	0.022	0.484 009	NS
	rs16970033	38033092	Intron 4	A/G	0.195	0.211	0.377 959	NS
	rs16970035	38033128	Intron 4	C/A	0.284	0.211	0.432 093	NS
	rs8041785	38039033	Intron 6	G/A	0.46	0.456	0.469 773	NS
	rs7174767	38057092	Intron 12	T/C	0.232	0.267	0.639 034	NS
	rs7173301	38057135	Intron 12	G/A	0.25	0.211	0.254 551	NS
	rs12442713	38068058	Intron 15	C/A	0.294	0.244	0.227 739	NS
	rs16970132	38069064	Intron 15	G/A	0.221	0.267	0.199 312	NS
	rs2291626	38077998	Intron 19	T/C	0.265	0.167	0.048 587	NS
	rs2412462	38088462	Intron 25	G/A	0.291	0.289	0.166 460	NS
	rs4432245	38111773	Intron 36	C/T	0.481 (0.473)	0.489	6.39×10−6 (0.03)	0.048
	rs711906	38112983	Intron 37	A/G	0.47 (0.471)	0.489	4.38×10−6 (0.01)	0.048

Note.

^AThe former allele represents the minor one of each locus;

^BMinor allele frequency calculated in initial GWA sample; data presented in parenthesis were the MAFs calculated in replication sample;

^CMinor allele frequency reported for the Chinese or Asians in the public database such as HapMap or dbSNP;

^DP value for association using single-SNP test in initial GWA sample; data presented in parenthesis were the P values for association in replication sample;

^EFDR q value is FDR correction value for multiple testing at the genome-wide level for initial GWA analysis; ‘NS’ means not significant.