Table 1. Electrophysiological properties of atrial myocytes incubated in palmitic (PA), stearic (SA), oleic (OA) acids and vehicle control (CTL).
| RMP (mV) | AP Amplitude (mV) | AP Overshoot (mV) | dv/dtmax (mV/msec) | Cell Cap (pF) | |
|---|---|---|---|---|---|
| CTL n = 9; N = 3 | -78.7 ± 0.90 | 106.5 ± 3.63 | 28.0 ± 3.44 | 227.9 ± 12.6 | 59.2 ± 2.94 |
| PA n = 12; N = 3 | -79.5 ± 0.81 | 118.8 ± 4.20 | 36.3 ± 3.26 | 231.8 ± 19.4 | 63.7 ± 5.15 |
| CTL n = 22; N = 5 | -79.2 ± 0.6 | 126.6 ± 2.52 | 34.0 ± 2.04 | 223.9 ± 13.1 | 63.1 ± 3.08 |
| SA n = 24; N = 5 | -80.3 ± 0.7 | 119.0 ± 2.92 | 34.3 ± 2.54 | 210.0 ± 13.8 | 53.8 ± 2.55* |
| CTL n = 6; N = 2 | -77.8 ± 0.74 | 119.0 ± 2.68 | 37.3 ± 1.92 | 192.5 ± 18.3 | 71.1 ± 5.98 |
| OA n = 5; N = 2CTL n = 6; N = 2 | -79.5 ± 1.21–77.8 ± 0.74 | 123.2 ± 4.02119.0 ± 2.68 | 38.0 ± 2.9237.3 ± 1.92 | 199.7 ± 12.0192.5 ± 18.3 | 64.9 ± 2.7971.1 ± 5.98 |
| OA n = 5; N = 2 | -79.5 ± 1.21 | 123.2 ± 4.02 | 38.0 ± 2.92 | 199.7 ± 12.0 | 64.9 ± 2.79 |
Acquisition of Resting Membrane Potential (RMP), Action Potential (AP) Amplitude, Action Potential Overshoot, dv/dtmax, and Cell Capacitance by patch clamp is presented with animal matched controls (CTL). (*p<0.05).