Table 1. The main assessment criteria for histologic skin lesions.
| Criterion | The degree of manifestation | Score |
|---|---|---|
| epidermal thickening | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| epidermal necrosis | absent | 0 |
| present | 1 | |
| epidermal hyperkeratosis | absent | 0 |
| present | 1 | |
| connective tissue like dermal proliferation | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| dermal necrosis | absent | 0 |
| present | 1 | |
| dermal swelling | absent | 0 |
| present | 1 | |
| dermal hemorrhage | absent | 0 |
| present | 1 | |
| connective tissue like subcutaneous fat proliferation | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| subcutaneous fat necrosis | absent | 0 |
| present | 1 | |
| subcutaneous fat swelling | absent | 0 |
| present | 1 | |
| subcutaneous fat hemorrhage | absent | 0 |
| present | 1 | |
| cell infiltration of dermis | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of dermis (eosinophils) | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of dermis (polynuclear leukocytes) | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of dermis (lymphocytes) | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of subcutaneous fat | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of subcutaneous fat (eosinophils) | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of subcutaneous fat (polynuclear leukocytes) | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 | |
| cell infiltration of subcutaneous fat (lymphocytes) | absent | 0 |
| mild | 1 | |
| moderate | 2 | |
| pronounced | 3 |
Each parameter had the degree of manifestation and appropriate score. The histological inflammatory index was calculated by averaging the sum of these scores.