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. 2015 Aug 14;10(8):e0135673. doi: 10.1371/journal.pone.0135673

Fig 2. Comparison of survival in metastatic colorectal cancer patients treated with irinotecan followed by oxaliplatin-based regimens or the reverse sequence.

Fig 2

The median first time to next treatment (TTNT1) in arm A (irinotecan followed by oxaliplatin-based regimens) was 210 days (14−2048). It was 196 days (14−2004) in arm B (oxaliplatin followed by irinotecan-based regimens). TTNT1 was not significantly different between patients in arm A and arm B (p = 0.17). Moreover, the median second time to next treatment (TTNT2) in arm A and arm B was 155 days (14−1666) and 123 days (14−1460), respectively. TTNT2 was longer for patients in arm A than for those in arm B (p = 0.006). In terms of overall survival (OS), the median OS time for arm A and arm B was 487 days (87−2161) and 454 days (56−1918), respectively. OS was significantly longer for patients in arm A than for those in arm B (p = 0.02).