Table 1. Comparison of Clinical Characteristics of Metastatic Colorectal Cancer Patients According to Front-line Treatment.
| Total | Supportive care | 5-Fluorouracil or Capecitabine alone | Irinotecan-based | Oxaliplatin-based | p value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (n = 9490) | (n = 3895) | (n = 1684) | (n = 1133) | (n = 2778) | ||||||||
| n (%) | n (%) | n (%) | n (%) | n (%) | ||||||||
| Age, years (mean ± SD) | 65.4 ± 14.2 | 71.5 ± 12.9 | 64.2 ± 13.7 | 59.2 ± 12.8 | 60.2 ± 13.5 | <0.001 a | ||||||
| <40 | 465 | (4.9) | 82 | (2.1) | 81 | (4.8) | 82 | (7.2) | 220 | (7.9) | <0.001 b | |
| 40−59 | 2683 | (28.3) | 618 | (15.9) | 515 | (30.6) | 468 | (41.3) | 1082 | (38.9) | ||
| ≧60 | 6342 | (66.8) | 3195 | (82.0) | 1088 | (64.6) | 583 | (51.5) | 1476 | (53.1) | ||
| Gender | 0.39 b | |||||||||||
| Female | 4101 | (43.2) | 1714 | (44.0) | 730 | (43.3) | 467 | (41.2) | 1190 | (42.8) | ||
| Male | 5389 | (56.8) | 2181 | (56.0) | 954 | (56.7) | 666 | (58.8) | 1588 | (57.2) | ||
| CCI (mean ± SD) | 1.1 ± 1.7 | 1.4 ± 1.9 | 1.0 ± 1.7 | 0.8 ± 1.4 | 0.8 ± 1.5 | <0.001 a | ||||||
| 0 | 4914 | (51.8) | 1687 | (43.3) | 896 | (53.2) | 666 | (58.8) | 1665 | (59.9) | <0.001 b | |
| 1−2 | 3267 | (34.4) | 1497 | (38.4) | 573 | (34.0) | 359 | (31.7) | 838 | (30.2) | ||
| ≧3 | 1309 | (13.8) | 711 | (18.3) | 215 | (12.8) | 108 | (9.5) | 275 | (9.9) | ||
| Hypertension | <0.001 b | |||||||||||
| No | 5961 | (62.8) | 2141 | (55.0) | 1105 | (65.6) | 803 | (70.9) | 1912 | (68.8) | ||
| Yes | 3529 | (37.2) | 1754 | (45.0) | 579 | (34.4) | 330 | (29.1) | 866 | (31.2) | ||
| Diabetes | <0.001 b | |||||||||||
| No | 7751 | (81.7) | 3053 | (78.4) | 1372 | (81.5) | 971 | (85.7) | 2355 | (84.8) | ||
| Yes | 1739 | (18.3) | 842 | (21.6) | 312 | (18.5) | 162 | (14.3) | 423 | (15.2) | ||
| Hyperlipidemia | 0.12 b | |||||||||||
| No | 8292 | (87.4) | 3425 | (87.9) | 1463 | (86.9) | 1005 | (88.7) | 2399 | (86.4) | ||
| Yes | 1198 | (12.6) | 470 | (12.1) | 221 | (13.1) | 128 | (11.3) | 379 | (13.6) | ||
| CVD | <0.001 b | |||||||||||
| No | 5260 | (55.4) | 1813 | (46.5) | 983 | (58.4) | 728 | (64.3) | 1736 | (62.5) | ||
| Yes | 4230 | (44.6) | 2082 | (53.5) | 701 | (41.6) | 405 | (35.7) | 1042 | (37.5) | ||
| CKD | <0.001 b | |||||||||||
| No | 9289 | (97.9) | 3763 | (96.6) | 1661 | (98.6) | 1121 | (98.9) | 2744 | (98.8) | ||
| Yes | 201 | (2.1) | 132 | (3.4) | 23 | (1.4) | 12 | (1.1) | 34 | (1.2) | ||
SD: standard deviation; CCI: Charlson comorbidity index; CVD: cardiovascular disease; CKD: chronic kidney disease.
aANOVA for continuous variables
bChi-square test for categorical variables.