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. 2015 Aug 14;10(8):e0135673. doi: 10.1371/journal.pone.0135673

Table 2. Comparison of Clinical Characteristics of Patients in Arm A and Arm B a .

Total (n = 1698) Arm A (n = 542) Arm B (n = 1156) p value
n (%) n (%) n (%)
Age, years (mean ± SD) 58.2 ± 12.8 58.4 ± 12.3 58.1 ± 13.0 0.67 b
    <40 133 (7.8) 34 (6.3) 99 (8.6) 0.23 c
    40−59 755 (44.5) 240 (44.3) 515 (44.6)
    ≥60 810 (47.7) 268 (49.4) 542 (46.9)
Gender 0.95 c
    Female 738 (43.5) 235 (43.4) 503 (43.5)
    Male 960 (56.5) 307 (56.6) 653 (56.5)
CCI (mean ± SD) 0.8 ± 1.3 0.7 ± 1.1 0.8 ± 1.4 0.78 b
    0 1026 (60.4) 315 (58.1) 711 (61.5) 0.18 c
    1−2 513 (30.2) 180 (33.2) 333 (28.8)
    ≥3 159 (9.4) 47 (8.7) 112 (9.7)
Hypertension 0.68 c
    No 1182 (69.6) 381 (70.3) 801 (69.3)
    Yes 516 (30.4) 161 (29.7) 355 (30.7)
Diabetes 0.95 c
    No 1455 (85.7) 464 (85.6) 991 (85.7)
    Yes 243 (14.3) 78 (14.4) 165 (14.3)
Hyperlipidemia 0.22 c
    No 1469 (86.5) 477 (88.0) 992 (85.8)
    Yes 229 (13.5) 65 (12.0) 164 (14.2)
CVD 0.90 c
    No 1077 (63.4) 345 (63.7) 732 (63.3)
    Yes 621 (36.6) 197 (36.3) 424 (36.7)
CKD 0.46 c
    No 1681 (99.0) 538 (99.3) 1143 (98.9)
    Yes 17 (1.0) 4 (0.7) 13 (1.1)

aArm A, irinotecan followed by oxaliplatin-based regimens; arm B, oxaliplatin followed by irinotecan-based regimens.

SD: standard deviation; CCI: Charlson comorbidity index; CVD: cardiovascular disease; CKD: chronic kidney disease.

bStudent’s t-test for continuous variables

cChi-square test for categorical variables.