Fig 7. Neuronal depolarisation induces the movement of Fox1 protein from cytoplasm to the nucleus where it is coded by RBFOX1 and increases its capacity to induce splice sites (1).

Gabrg2 is regulated by RBFOX1 through the binding of Fox1 protein 1 and Nova near the 5′ and 3′ splice sites of the downstream intron through the targeting of the RNA hexanucleotide UGCAUG (2). Binding to the conserved UGCAUG elements cause an inclusion of 8 amino acids (LLRMFSFK) on the intracellular loop between the M3 and M4 transmembrane domain site. This creates a putative for protein kinase C (PKC) which is a point for serine phosphorylation (3). Phosphorylation of serine alters the γ2 subunit structure of the GABA (A) receptor which controls the regulation of GABAergic neuronal transmission (4).