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. 2015 Aug 14;10(8):e0133650. doi: 10.1371/journal.pone.0133650

Fig 4. Level of NZB mtDNA in heteroplasmic mouse embryos produced by cytoplasmic transfer.

Fig 4

Zygotes were centrifuged prior to cytoplasmic transfer to enable production of embryos with higher levels of NZB mtDNA (filled circles). For comparison, cytoplasmic transfer was also performed without centrifugation (empty circles). Embryos from both groups were evaluated with regards to the level of NZB mtDNA at the zygote and blastocyst stages by ARMS-qPCR. Bars represent the means. P values for the effect of Group, Stage and Group x Stage are denoted in the inset.