Table 4.

Univariate and multivariable Cox analysis for overall survival

OS	Univariate Cox regression		Multivariable Cox regression
	HR (95% CI)	p value	HR (95% CI)	p value
Heng prognostic group
Good vs. poor	0.15 (0.07–0.31)	<0.001	0.17 (0.08–0.37)	<0.001
Intermediate vs. poor	0.28 (0.16–0.53)	<0.001	0.27 (0.15–0.50)	<0.001
BM (Y/N)	1.84 (1.25–2.72)	0.002	1.81 (1.21–2.70)	0.003
Sites of metastases ≥ 2 (Y/N)	1.72 (0.92–3.23)	0.088
Therapy (SO vs. EV)	2.43 (1.65–3.63)	<0.001	2.21 (1.47–3.31)	<0.001

OS: overall survival; BM: bone metastases, CI: confidence interval; HR: hazard ratio; Y: yes; N: no; EV: everolimus; SO: sorafenib.