Table 1.
Characteristics* of Men without Clinical Indication for Biopsy and Negative for Prostate Cancer by Tertile of Serum PSA at Biopsy, Placebo Arm, Prostate Cancer Prevention Trial
| Tertile of PSA Concentration at Biopsy (ng/mL) |
||||
|---|---|---|---|---|
| 1 (>0 to ≤0.8) |
2 (>0.8 to ≤1.5) |
3 (>1.5 to <4.0) |
P-trend | |
| N | 77 | 71 | 76 | |
| Mean Age at Baseline (years) | 63 | 64 | 65 | 0.1 |
| Mean Age at Biopsy (years) | 70 | 71 | 72 | 0.1 |
| Non-White (%) | 16.4 | 15.4 | 16.3 | 1.0 |
| Family History (%) | 15.3 | 25.3 | 13.5 | 0.8 |
| Cigarette Smoking History (%) | ||||
| Current | 5.3 | 8.5 | 3.8 | 0.7 |
| Former | 61.4 | 67.6 | 60.1 | 0.9 |
| Never | 33.3 | 23.9 | 36.1 | 0.7 |
| Mean Body Mass Index (kg/m2) | 27.9 | 27.6 | 27.5 | 0.5 |
| History of Diabetes (%) | 13.0 | 7.0 | 9.2 | 0.4 |
| Mean Cholesterol Concentration (mg/dL) | 207 | 200 | 204 | 0.6 |
| Prior Prostate Biopsy (%) | 15.1 | 15.6 | 16.2 | 0.9 |
| Prior or Current Prostatitis (%) | 7.7 | 1.4 | 9.3 | 0.7 |
| Prior or Current Aspirin Use (%) | 11.8 | 24.0 | 19.6 | 0.2 |
| Prior or Current Non-steroidal Anti-inflammatory Drug Use (%) | 40.0 | 19.7 | 29.2 | 0.1 |
| Mean PSA Concentration (ng/mL) | ||||
| Baseline | 0.61 | 1.04 | 1.67 | <0.0001 |
| Biopsy | 0.56 | 1.18 | 2.46 | <0.0001 |
| Mean Prostate Volume (mL) | 29.1 | 35.8 | 43.3 | <0.0001 |
*
Baseline characteristics except where otherwise noted. For all characteristics except age at baseline, from generalized models (linear for adjusted proportions and means and logistic for P-trends) adjusting for baseline age.