Table 2.

Predictors of all-cause mortality in asymptomatic individuals with and without coronary artery calcification.

	Model 1		Model 2
	Overall (N=9715)		CAC=0 (N=4864)		CAC>0 (N=4851)
	Univariable	Multivariable	Univariable	Multivariable	Univariable	Multivariable
CAC>0	3.36 (2.89–3.90)	2.67 (2.29–3.11)	NA	NA	NA	NA
	p<0.001	p<0.001
Age	1.04 (1.04–1.05)	1.04 (1.03–1.05)	1.03 (1.02–1.04)	1.03 (1.02–1.04)	1.05 (1.04–-1.05)	1.05 (1.04–1.05)
	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001
Female	1.05 (0.93–1.20)	0.96 (0.84–1.09)	1.08 (0.83–1.40)	1.01 (0.78–1.32)	1.10 (0.94–1.27)	0.93 (0.80–1.09)
Gender	p=0.42	p=0.54	p=0.58	1.02 p=0.92	p=0.23	p=0.37
Hypertension	1.90 (1.67–2.16)	1.61 (1.41–1.84)	1.68 (1.30–2.18)	1.58 (1.21–2.06)	1.66 (1.43–1.94)	1.62 (1.39–1.89)
	p<0.001	p<0.001	p<0.001	p=0.001	p<0.001	p<0.001
Dyslipidemia	0.81 (0.71–0.92)	0.69 (0.60–0.79)	0.93 (0.72–1.21)	0.83 (0.63–1.08)	0.66 (0.57–0.76)	0.65 (0.56–0.75)
	p=0.002	p<0.001	p=0.60	p=0.16	p<0.001	p<0.001
Diabetes	2.98 (2.54–3.49)	2.22 (1.89–2.61)	2.84 (1.97–4.11)	2.53 (1.74–3.69)	2.48 (2.08–2.97)	2.15 (1.79–2.57)
	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001
Family History	0.75 (0.65–0.85)	0.76 (0.67–0.87)	0.93 (0.70–1.23)	0.93 (0.70–1.23)	0.71 (0.61–0.83)	0.71 (0.61–0.83)
	p<0.001	p<0.001	p=0.61	p=0.61	p<0.001	p<0.001
Smoking	1.91 (1.68–2.17)	1.79 (1.58–2.04)	1.92 (1.48–2.48)	1.95 (1.50–2.53)	1.64 (1.41–1.90)	1.77 (1.52–2.05)
	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001
	Model 3		Model 4
FRS, per 5%	1.21 (1.18–1.24)	1.17 (1.15–1.20)	1.17 (1.11–1.24)	1.18 (1.11–1.24)	1.17 (1.14–1.20)	1.17 (1.14–1.21)
risk increase23	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001
NCEP ATP III	1.29 (1.25–1.34)	1.23 (1.19–1.28)	1.28 (1.19–1.37)	1.28 (1.19–1.37)	1.21 (1.17–1.27)	1.22 (1.17–1.27)
per 5% risk	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001	p<0.001
increase3

Model 1 adjusted for presence of coronary artery calcium, age, gender, and cardiovascular morbidities, including cigarette smoking, diabetes, hypertension, dyslipidemia and family history of premature coronary artery disease. Model 2 adjusted for age, gender, and cardiovascular morbidities, including cigarette smoking, diabetes, hypertension, dyslipidemia and family history of premature coronary artery disease. Model 3 adjusted for presence of coronary artery calcium, and family history of premature coronary artery disease. Model 4 adjusted for family history of premature coronary artery disease.

Abbreviations: CAC, coronary artery calcium; FRS, Framingham Risk Score; NCEP ATP III, National Cholesterol Education Program Adult Treatment Panel III.