Table 1.
MiRNAs implicated in Stress and MDD
| miRNAs | Effects | References |
|---|---|---|
| Restraint stress | Frontal cortex: miR-9, miR-9*, miR-26b, miR-29b, miR-30b, miR-30c, miR-30e, miR-125a, miR-126-3p, miR-129-3p, miR-207, miR-212, miR-351, miR-423, miR-487b, miR-494, miR-690, miR-691, miR-709, miR-711, and Let-7 a–e let-7a, miR-9, miR-26a/b, miR-30b/c, and miR-125a | Rinaldi et al., 2010 |
| Immobilization stress | Hippocampus CA1, amygdala: miR-134, miR-183, miR-132, Let-7a-1, miR-9-1, and miR-124a-1 | Meerson et al., 2010 |
| Unpredictable chronic mild stress | Hippocampus: miR298, miR-130b, miR-135a, miR-323, miR-503, miR-15b, miR-532, and miR-125a and up-regulating miRNAs miR7a, miR-212, miR-124, miR-139, and miR-182 | Cao et al., 2013 |
| Early life stress | Medial prefrontal cortex: pre-miRs 132, 124-1, 9-1, 9-3, 212, and 29a | Uchida et al., 2013 |
| Animal model of depression | Learned helpless vs. Control frontal cortex: mmu-miR-184, mmu-miR-197, mmu-miR-107, mmu-miR-329, mmu-miR-125a-5p, mmu-miR-872, mmu-miR-181c, mmu-miR-18a*, mmu-miR-29b*, mmu-let-7a*, rno-let-7e*, rno-miR-20a* | Smalheiser et al., 2011 |
| Postmortem brain studies | Prefrontal cortex: hsa-miR-142-5p, hsa-miR-33a, hsa-miR-137, hsa-miR-489, hsa-miR-148b, hsa-miR-101, hsa-miR-324-5p, hsa-miR-301a, hsa-miR-146a, hsa-miR-335, hsa-miR-494, hsa-miR-20b, hsa-miR-376a*, hsa-miR-190, hsa-miR-155, hsa-miR-660, hsa-miR-552, hsa-miR-453, hsa-miR-130a, hsa-miR-27a, hsa-miR-497, hsa-miR-10a, hsa-miR-20a, hsa-miR-142-3p | Smalheiser et al., 2012 |
| Peripheral mononuclear cells | has-miR-107, miR-133a, miR-148a, miR-200c, miR-381, miR-425-3p, miR-494, miR-517b, miR-579, miR-589, miR-636, miR-652, miR-941, miR-1243 | Belzeaux et al., 2012 |
| Whole blood cells (12 weeks of treatment with escitalopram) | hsa-miR-130b, hsa-miR-505, hsa-miR-29b-2, hsa-miR-26b, hsa-miR-22, hsa-miR-26a, hsa-miR-664, hsa-miR-494, hsa-let-7d, hsa-let-7g, hsa-let-7e, hsa-miR-34c-5p, hsa-let-7f, hsa-miR-629, hsa-miR-106b, hsa-miR-103, hsa-miR-191, hsa-miR-128, hsa-miR-502-3p, hsa-miR-374b, hsa-miR-132, hsa-miR-30d hsa-miR-500, hsa-miR-770-5p, has-miR-589, hsa-miR-183, hsa-miR-574-3p, hsa-miR-140-3p, hsa-miR-335, hsa-miR-361-5p | Bocchio-Chiavetto et al., 2012 |
| PBMC study in MDD patients | miRNA-26b, miRNA-1972, miRNA-4485, miRNA-4498, and miRNA-4743 | Fan et al., 2014 |
| Fluoxetine treatment | MiR-19 and target gene SERT | Launay et al., 2011 |
| Acute and chronic ECS treatment | BDNF modulation associated increased miR-212 | Ryan et al., 2013 |
| Genetically modified mouse model | miR-135 associated with anxiety-and depression-like behaviors, 5HT levels, and behavioral response to antidepressant treatment | Issler et al., 2014 |
| Genetic polymorphism and late insomnia in MDD | rs76481776 polymorphism in the pre-miR-182 associated with Clock genes | Saus et al., 2010 |
| Genetic polymorphism and P300 latency in MDD | P300 latency in MDD patients was associated with miR-30e ss178077483 genotypes and the individuals with the C/T genotype had a longer P300 latency than those carrying the C/C genotype. | Xu et al., 2010 |