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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Int J Cancer. 2015 Feb 27;137(5):1085–1094. doi: 10.1002/ijc.29480

Figure 4.

Figure 4

Depletion of MDSC or Kupffer cells exacerbates liver metastasis. (a) Liver metastases and (b) Cytolytic activity of liver NK cells isolated from anti-Gr1 antibody-treated NKT cell-deficient mice and tested against B16LS9 melanoma target cells. (c) Liver metastases in anti-Gr1-treated mice and isotype control-treated mice. (d) Number of surface liver metastases following depletion of neutrophils with anti-Ly6G antibody (e) Liver metastases in mice treated with PBS-containing liposomes or (f) Clodronate-containing liposomes. (g) Number of liver metastases in mice treated with either clodronate-containing liposomes or PBS-containing liposomes. There were 10 mice/group. These experiments were performed twice with similar results. Results are expressed as Mean +/− SD and are representative of two independent experiments. ** P= 0.001.