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. 2014 Apr 3;25(9):2648–2657. doi: 10.1093/cercor/bhu063

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — fMRI activations in the mPFC associated with self/other recollection. Effects in A and B are thresholded at P < 0.001 (uncorrected), with a minimum cluster size of 10 voxels, and inclusively masked to display only activations within the mPFC region associated with social cognition in Amodio and Frith (2006). Effects in (C) are thresholded at P < 0.05 family-wise error corrected for the whole brain, with a minimum cluster size of 10 voxels. The percent signal change bar graphs (A and B) plot the mean difference between each displayed condition and the nonepisodic Control task extracted from the peak voxel in each mPFC cluster. (A) A dorsal mPFC region with a peak at [−12, 59, 25] showed enhanced activation for both old and new items in both recollection tasks, compared with the Control condition. (B) a ventral mPFC region with a peak at [−9, 53, 13] showed selective activation for old items that participants had processed in relation to their conceptual self during study, and only when the retrieval task required recollection of conceptual self/other information. (C) In a whole-brain analysis, general old > new effects (old > new collapsed across retrieval task; red) were associated with a very different activation pattern from episodic retrieval task effects (episodic tasks > Control task; green), except in the precuneus where the 2 effects overlapped.