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. 2014 May 16;25(9):3025–3035. doi: 10.1093/cercor/bhu098

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© The Author 2014. Published by Oxford University Press

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Inhibitory transmission onto pyramidal neurons in L2/3 of deprived cortex is unaltered by short periods of whisker deprivation. (A) Schematic showing an FS interneuron synaptically connected to a pyramidal cell (top); train of 8 action potentials in the presynaptic FS interneuron generates 8 short latency uIPSPs in the postsynaptic pyramidal neuron (average of 50 trials). Scale bars (top to bottom): 20 mV, 0.1 mV, 100 ms. (B) Percentage of tested FS interneuron to pyramidal cell pairs (FS → Pyr) that were synaptically connected in control (black, 62%) and deprived (red, 64%) cortex. (C) Empirical distribution plots of the amplitudes of mean uIPSP1 (absolute value) in deprived (red) and control (black) cortex. Median [IQR] of mean uIPSP1 amplitudes: deprived: −0.24 [−0.35 to −0.18] mV, n = 16 FS → Pyr connections; control, −0.27 [−0.69 to −0.20] mV, n = 19 FS → Pyr connections. (D) Mean uIPSP amplitude during 20 Hz trains in deprived (red, n = 8 FS → Pyr connections) and control (black, n = 13 FS → Pyr connections) cortex. Error bars, SEM. (E) uIPSP amplitudes during a 20-Hz train normalized to uIPSP1 for each L2/3 FS → Pyr connection in 3-day deprived cortex (red, n = 8) and in control cortex (black, n = 13). Error bars are within the majority of circles. (F) Relationship between mean uEPSP1 amplitude and mean uIPSP1 amplitude (absolute values) for pairs of reciprocally connected FS interneurons and pyramidal cells in control (black) and deprived (red) cortex (correlation: deprived, r = −0.40, n = 14 reciprocally connected FS → Pyr pairs; control, r = −0.06, n = 17 reciprocally connected FS → Pyr pairs).