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. 2015 Aug 15;10(5):35. doi: 10.1007/s12263-015-0484-0

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Vitamin D-microRNA network. MicroRNA–target interactions from TargetScan and miRTarBase were added to the vitamin D-extended network. Six out of nine differentially expressed microRNAs in 1,25(OH)₂D₃-treated cancer cells were present in the vitamin D-microRNA network. Those six up-regulated microRNAs are highlighted as green rounded rectangles. Together they target 96 gene products present in pathways (diamonds) and added with protein–protein and transcription factor–gene interactions (ellipses). Up-regulated genes are coloured in red, and down-regulated genes are coloured in blue. The edge colour indicates the source, either TargetScan (blue) or miRTarBase (red). Seven target interactions are present in both databases