Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 30;162(3):607–621. doi: 10.1016/j.cell.2015.06.060

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Functional Modules Determined for Zfhx3^Sci/+ SCN Expression

(A) The consensus AT motif derived from published AT sequences of genes regulated by Zfhx3 (see Experimental Procedures).

(B) A protein-protein interaction network representing the differentially expressed transcripts in Zfhx3^Sci/+ SCN for all modules. Clustering analysis compartmentalized the network into modules of densely connected nodes. Positive identification of the consensus AT motif within the promoter regions of these transcripts is denoted by yellow shading. Node shape denotes the significance at different time points. Module 1 contains the greatest number of downregulated genes, AT motifs, and connectivity compared to other modules.

(C) The top nine overrepresented GO terms for genes in module 1. The number downregulated (gray) and number upregulated (blue) are listed for each term. Neuropeptide and signaling activities are among the top functional roles of the genes in this module.

See also Tables S3 and S4.