Table 2.
Overlap of complex trait-associated genetic variants and the identified PM2.5-asociated H3K27ac loci
| Complex trait | SNP ID | Region | Reported gene | Context | PubMed reference |
|---|---|---|---|---|---|
| Inflammatory bowel disease | rs12654812 | 5q35.3 | DOK3 | intron | 23128233 |
| Renal function-related traits | rs12654812 | 5q35.3 | RGS14 | intron | 22797727 |
| Suicide attempts in depression or bipolar disorder | rs17173608 | 7q36.1 | RARRES2 | intron | 24964207 |
| IgG glycosylation | rs11994937 | 8q12.1 | - | intron | 23382691 |
| Fibrinogen | rs7464572 | 8q24.3 | PLEC1 | intron | 23969696 |
| Metabolic traits | rs6558295 | 8q24.3 | OPLAH | intron | 21886157 |
| Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) | rs10785877 | 9q34.2 | RXRA | - | 23648065 |
| Alzheimer’s disease | rs3764650 | 19p13.3 | ABCA7 | intron | 21460840 |
| rs115550680 | 19p13.3 | ABCA7, HMHA1, GRIN3B | intron | 23571587 | |
| Red blood cell traits | rs737092 | 20q13.31 | RBM38 | - | 23222517 |
| Cognitive decline (age-related) | rs9980664 | 21q22.11 | Intergenic | - | 24468470 |