Table 3.
HIV-1 viral load and CD4+ T cell counts of individuals with major protease inhibitor drug resistance mutations
| ID | Mutation | Age, years | Gender | ART duration, years | HIV-1 RNA (log10 HIV-1 RNA), copies/ml | CD4+ T cells/ml |
|---|---|---|---|---|---|---|
| #1 | D30N + M46I + G48E | 36.4 | M | <0.5 | 4624 (3.7) | 473 |
| #2 | L90M + K20R | 34.6 | M | 1–3 | 291,124 (5.5) | 637 |
| #3 | D30N + M46I + K20I | 30.1 | F | 1–3 | 141,341 (5.2) | 39 |
| #4 | D30N + T74S + K20R | 33.3 | M | Naive | 209,871 (5.3) | 162 |
Mutations are denoted according to Stanford drug resistance database and International Antiviral Society-USA drug resistance mutations panel [12, 39, 40]
Major mutations are shown in bold
D aspartic acid, E glutamic acid, G glycine, I isoleucine, K lysine, L leucine, M methionine, N asparagine, S serine; T threonine, ART antiretroviral therapy, HIV-1 human immunodeficiency virus type-1