Table 4.

Association between minor protease inhibitor resistance mutations, viral load and CD4+ T cell count

	Injection drug users
	ART (−)			ART (+)
	Mutation (−), n = 18	Mutation (+), n = 13	P	Mutation (−), n = 30	Mutation (+), n = 14	P
CD4+ T cell count/μl	529 (276)	568 (597)	0.708	412 (415)	424 (648)	0.762
Log10 HIV-1 RNA, copies/ml	4.4 (2.7)	2.2 (1.9)	0.183	3.6 (2.7)	2.2 (1.7)	0.142

	Non-drug users
	ART (−)			ART (+)
	Mutation (–), n = 7	Mutation (+), n = 14	P	Mutation (−), n = 17	Mutation (+), n = 15	P
CD4+ T cell count/μl	989 (507)	455 (599)	0.005	351 (526)	554 (461)	0.350
Log10 HIV-1 RNA, copies/ml	3.6 (1.9)	4.8 (2.5)	0.313	4.3 (1.3)	4.3 (2.0)	0.852

Data presented are medians (IQR, interquartile range) in carriers and non-carriers of only minor protease resistance mutations. Statistical analysis was performed using Mann–Whitney test

Significant P-values are shown in italic

ART (−) anti-retroviral treatment-naive, ART (+) anti-retroviral treatment-experienced, Mutation (+) minor protease resistance mutation carrier, Mutation (−) minor protease resistance mutation non-carrier, HIV-1 human immunodeficiency virus type